When he grew to a youth, Raghunātha Bhaṭṭa traveled to Jagannātha Purī for the association of Mahāprabhu, where he stayed and served the Lord for ten months. Raghunātha was an expert cook and regularly prepared many delicious meals for the Lord. Śrīman Mahāprabhu happily accepted the offerings of Raghunātha, which were cooked with so much sweetness and love.
Raghunātha Bhaṭṭa had a sweet voice like a cuckoo bird and was especially gifted in the recitation and explanation of the Śrīmad-Bhāgavatam. He sang the verses of the Bhāgavatam in many beautiful, heart-rending melodies, and by his descriptions, he decorated the devotees and nourished them with bhāgavata- rasa, the transcendental nectar of divine love. Mahāprabhu encouraged Raghunātha to recite the Bhāgavatam and would even listen to him speak the Bhāgavatam before the assembly of devotees.
After ten months with Mahāprabhu, the Lord instructed Raghunātha Bhaṭṭa to return home to his parents in Vārāṇasī and later he could come back to him in Purī. Raghunātha accepted the order of the Lord, despite the intense pain of ensuing separation. He came back to Mahāprabhu a few years hence and stayed again for ten months. Mahāprabhu then told Raghunātha to go to Vṛndāvana and stay with the other Gosvāmīs, led by Śrī Rūpa and Sanātana, and to there preach the glories of the Bhāgavatam and serve all the Vaiṣṇavas.
In Vṛndāvana, Raghunātha Bhaṭṭa Gosvāmī nourished everyone with pure love for Śrī Śrī Rādhā-Kṛṣṇa. He established many temples and gave shelter to countless living entities. He took responsibility for the spiritual development of all souls. He concluded his pastimes on this Earth in the transcendental abode of Śrī Vṛndāvana and re-entered the eternal pastimes of Śrī Śrī Rādhā-Kṛṣṇa.